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Invitrogen
Ataxin 3 Recombinant Rabbit Monoclonal Antibody (7B2I1)
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Ataxin 3 Antibody (MA5-51244) in WB
Western blot analysis of Ataxin 3 in extracts from various lysates. Samples were incubated with Ataxin 3 Recombinant monoclonal antibody (Product # MA5-51244) using a dilution of 1:2,000 followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
MA5-51244
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7B2I1
抗原
Recombinant Protein (or fragment)
偶联物
形式
Liquid
浓度
0.53 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KLIGEELAQL KEQRVHKTDL ERVLEANDGS GMLDEDEEDL QRALALSRQE IDMEDEEADL RRAIQLSMQG SSRNISQDMT QTSGTNLTSE ELRKRREAYF EKQQQKQQQQ QQQQQQGDLS GQSSHPCERP ATSSGALGSD LGDAMSEEDM LQAAVTMSLE TVRNDLKTEG KK
靶标信息
Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ataxin-3; ataxin3; Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog; Machado-Joseph disease protein 1 homolog; spin
基因别名: 2210008M02Rik; AI463012; AI647473; ataxin-3; ATX3; Atxn3; Mjd; MJD1; Rsca3; Sca3
UniProt ID: (Rat) O35815, (Mouse) Q9CVD2
Entrez Gene ID: (Rat) 60331, (Mouse) 110616
RNA polymerase II regulatory region DNA binding
histone deacetylase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
omega peptidase activity
ubiquitin protein ligase binding
identical protein binding
ATPase binding
Lys63-specific deubiquitinase activity
Lys48-specific deubiquitinase activity
peptidase activity
cysteine-type peptidase activity
hydrolase activity
chromatin/chromatin-binding, or -regulatory protein
microtubule cytoskeleton organization
transcription, DNA-templated
regulation of transcription, DNA-templated
ubiquitin-dependent protein catabolic process
misfolded or incompletely synthesized protein catabolic process
regulation of cell-substrate adhesion
actin cytoskeleton organization
cellular response to heat
monoubiquitinated protein deubiquitination
exploration behavior
proteasome-mediated ubiquitin-dependent protein catabolic process
intermediate filament cytoskeleton organization
protein K63-linked deubiquitination
histone H3 deacetylation
protein K48-linked deubiquitination
cellular response to misfolded protein
proteolysis
