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Invitrogen
Aurora A/B Monoclonal Antibody (3H1)
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Aurora A/B Antibody (MA5-47418) in ICC/IF
Immunofluorescent analysis of Aurora A in HeLa cell culture. Samples were stained with Aurora A monoclonal antibody (Product # MA5-47418) in green. Costained with chicken pAb to vimentin in red. The blue is DAPI staining of nuclear DNA. The aurora A antibody stains spindle poles and mitotic spindles at anaphase and concentrates on the midbody between the two daughter cells during telophase.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-47418
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3H1
抗原
Full length recombinant human Aurora A protein expressed in and purified from E. coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS with 50% glycerol
内含物
5mM sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The Aurora gene, a serine-threonine kinase, orginally discovered in Drosophila, has been found to be responsible for a chromosomal segregation defect. The mammalian homologues of Drosophila Aurora have been termed ARK1 (Aurora-related kinase 1) and ARK2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AIM-1; ARK-1; ARK-2; Aurora 1; Aurora 2; aurora A; aurora B; aurora family kinase 1; Aurora kinase A; Aurora kinase B; Aurora- and IPL1-like midbody-associated protein 1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; Aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; Breast tumor-amplified kinase; Ipl1- and aurora-related kinase 1; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 6; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase Ayk1; STK-1
基因别名: AIK; AIK2; AIM-1; AIM1; AIRK1; AIRK2; AL022959; ARK-1; ARK-2; ARK1; ARK2; AU019385; AURA; AurB; AURKA; AURKB; Aurora-A; AW539821; AYK1; BTAK; IAK; IAK1; IPL1; STK-1; STK1; STK12; STK15; STK5; STK6
UniProt ID: (Mouse) P97477, (Mouse) O70126, (Rat) O55099
Entrez Gene ID: (Mouse) 20878, (Rat) 261730, (Mouse) 20877, (Rat) 114592
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
ubiquitin protein ligase binding
histone serine kinase activity
metal ion binding
non-receptor serine/threonine protein kinase
meiotic spindle organization
microtubule cytoskeleton organization
mitotic cell cycle
protein phosphorylation
cell cycle
spindle organization
mitotic spindle organization
spindle assembly involved in female meiosis I
mitotic nuclear division
mitotic centrosome separation
meiotic nuclear division
anterior/posterior axis specification
phosphorylation
cell projection organization
regulation of protein stability
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cytokinesis
histone-serine phosphorylation
negative regulation of apoptotic process
centrosome organization
cell division
centrosome localization
protein localization to centrosome
negative regulation of spindle checkpoint
positive regulation of oocyte maturation
neuron projection extension
response to estradiol
negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
spindle checkpoint
positive regulation of cytokinesis
protein localization to kinetochore
cellular response to UV
cleavage furrow formation
histone H3-S28 phosphorylation
mitotic spindle midzone assembly
aging
cell proliferation
abscission
negative regulation of cytokinesis
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