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Invitrogen
Aurora B/C Polyclonal Antibody
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产品信息
PA5-103185
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human AURKB(Accession Q96GD4), corresponding to amino acid residues M1-A38.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total AurB/C.
靶标信息
Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AIM-1; ARK-2; ARK-3; Aurora 1; Aurora 3; aurora B; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora kinase C; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; aurora-related kinase 3; Aurora/IPL1-related kinase 2; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 1; Aurora/IPL1/Eg2 protein 2; epididymis secretory protein Li 90; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine kinase 13 (aurora/IPL-like); serine/threonine kinase 13 (aurora/IPL1-like); serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase aurora-C; STK-1
基因别名: AIE1; AIE2; AIK2; AIK3; AIM-1; AIM1; AIRK2; AIRK3; AL022959; ARK-2; ARK-3; ARK2; ARK3; AurB; AurC; AURKB; aurkb-sv1; aurkb-sv2; AURKC; aurora-C; HEL-S-90; IAK3; IPL1; PPP1R48; SPGF5; STK-1; STK1; STK12; STK13; STK5
UniProt ID: (Human) Q96DV5, (Human) Q9UQB9, (Mouse) O70126, (Rat) O55099, (Mouse) O88445
Entrez Gene ID: (Human) 9212, (Human) 6795, (Mouse) 20877, (Rat) 114592, (Mouse) 20871, (Rat) 292554
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
histone serine kinase activity
metal ion binding
protein kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
protein phosphorylation
spindle organization
sister chromatid cohesion
aging
cell proliferation
attachment of spindle microtubules to kinetochore
abscission
histone modification
protein sumoylation
anaphase-promoting complex-dependent catabolic process
spindle checkpoint
negative regulation of protein binding
positive regulation of telomere maintenance via telomerase
negative regulation of cytokinesis
positive regulation of cytokinesis
protein localization to kinetochore
cellular response to UV
cleavage furrow formation
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
histone H3-S28 phosphorylation
protein autophosphorylation
mitotic spindle midzone assembly
positive regulation of telomerase activity
regulation of chromosome segregation
regulation of signal transduction by p53 class mediator
positive regulation of telomere capping
cytokinesis
spermatogenesis
histone-serine phosphorylation
oocyte development
meiotic cell cycle
cell cycle
mitotic spindle organization
mitotic nuclear division
phosphorylation
regulation of cytokinesis
cell division
regulation of signal transduction
