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Influenza A H7N9 is a subtype of the influenza virus distinguished by its hemagglutinin H7 and neuraminidase N9 proteins. The neuraminidase (NA) component is a critical enzyme enabling viral release from infected cells, facilitating the spread of virions within the host. The structure of NA in H7N9 is pivotal for understanding its role in viral pathogenicity and drug resistance. Mutations in NA, such as NA-I222T and NA-H274Y, contribute to antiviral resistance, especially against neuraminidase inhibitors like oseltamivir, which are commonly used therapeutics. These mutations affect the catalytic efficiency and binding affinity of NA for its inhibitors, posing challenges to clinical management and emphasizing the necessity for ongoing surveillance and molecular characterization. The immunogenicity of vaccines targeting both HA and NA proteins is being explored to enhance protective responses against diverse influenza strains. Understanding the evolution and function of H7N9 NA informs the development of effective vaccines and contributes to the strategic planning for influenza outbreak prevention and control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。