Invitrogen

Axl Monoclonal Antibody (7E10)

Name: Axl Monoclonal Antibody (7E10)
Brand: Invitrogen
SKU: MA5-15504

1个已发表图片

2 篇参考文献

查看其他57个AXL抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)
已发表图片 (1)

Axl Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 3

Axl Antibody (MA5-15504) in ICC/IF

Immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-human IgG Fc using AXL monoclonal antibody (Product # MA5-15504) (Green). Blue: DRAQ5 fluorescent DNA dye.

Axl Antibody in Immunohistochemistry (IHC)

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产品信息

MA5-15504

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:200-1:1,000

酶联免疫吸附实验 (ELISA)

1:10,000

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

7E10

抗原

Purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

ascites

内含物

0.03% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_10978746

产品详细信息

MA5-15504 targets AXL in indirect ELISA, IF and WB applications and shows reactivity with Human samples.

The MA5-15504 immunogen is purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line.

MA5-15504 detects AXL which has a predicted molecular weight of approximately 97.4kDa.

靶标信息

AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells. Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form. Increased plasma levels may be indicative of inflammation and cancer.

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