Invitrogen

Azurocidin Monoclonal Antibody (z6718)

Name: Azurocidin Monoclonal Antibody (z6718)
Brand: Invitrogen
SKU: MA5-33334

查看其他13个Azurocidin抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

MA5-33334

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-Dependent

免疫组化（冰冻） (IHC (F))

Assay-Dependent

免疫细胞化学 (ICC/IF)

Assay-Dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

z6718

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

100 µg/mL

纯化类型

Protein G

保存液

PBS with 0.1% BSA

内含物

0.02% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2815472

产品详细信息

In Western Blot application testing, this antibody detected a 37 kDa protein. A non-reduced sample treatment and SDS-Page was used.

Product is supplied at 1 mL (100 µL/mL).

靶标信息

Azurocidin, also called heparin-binding protein (HBP), is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C. albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulation of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via beta 2-intergrins. High plasma levels of azurocidin might help with the identification of patients which are at risk in developing sepsis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。