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Invitrogen
B-Raf (L597R Mutant) Recombinant Rabbit Monoclonal Antibody (HL4011)
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B-Raf (L597R Mutant) Antibody (MA568379) in ICC/IF
Immunocytochemistry analysis of B-Raf (L597R Mutant) in Mock and transfected 293T cells were fixed in 4% paraformaldehyde at RT for 15 min. Samples were incubated with B-Raf (L597R Mutant) recombinant monoclonal antibody (Product # MA568379) using a dilution of 1:500 (Green). Fluoroshield with DAPI (Blue).
产品信息
MA568379
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL4011
抗原
Synthetic peptide of human B-Raf (L597R Mutant).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The B-Raf (L597R Mutant) refers to a specific mutation in the B-Raf gene where leucine at position 597 is replaced by arginine. This mutation significantly affects the MAPK/ERK signaling pathway, which is crucial for cell growth and differentiation. Unlike the more common B-Raf V600E mutation, the L597R mutation results in variations in kinase activity that can contribute to tumorigenesis in certain cancers, including melanoma and colorectal cancer. The L597R mutation alters the structure of the B-Raf protein, leading to changes in its interaction with other molecules within the signaling pathway. Research has shown that this mutation can activate downstream signaling targets in a manner distinct from other mutations, thereby driving oncogenic processes. Studies on inhibitors targeting the L597R mutation are ongoing, aiming to develop precision medicine approaches that can specifically inhibit this mutant's activity to provide therapeutic benefits for affected patients. Understanding the biochemical properties and effects of the B-Raf L597R mutation continues to be a critical area of focus for devising effective cancer treatments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 94 kDa B-raf protein; B-Raf L597R; B-Raf proto-oncogene serine/threonine-protein kinase (p94); murine sarcoma viral (v-raf) oncogene homolog B1; p94; Proto-oncogene B-Raf; Serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B; v-Raf murine sarcoma viral oncogene homolog B1
基因别名: B-raf; B-RAF1; BRAF; BRAF1; NS7; RAFB1
UniProt ID: (Human) P15056
Entrez Gene ID: (Human) 673
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
calcium ion binding
protein binding
ATP binding
small GTPase binding
mitogen-activated protein kinase kinase binding
identical protein binding
protein heterodimerization activity
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPKK activity
myeloid progenitor cell differentiation
protein phosphorylation
visual learning
organ morphogenesis
positive regulation of gene expression
negative regulation of fibroblast migration
glucose transport
thyroid gland development
positive regulation of peptidyl-serine phosphorylation
somatic stem cell population maintenance
cellular response to drug
regulation of cell proliferation
negative regulation of apoptotic process
CD4-positive, alpha-beta T cell differentiation
positive T cell selection
response to peptide hormone
negative regulation of neuron apoptotic process
thymus development
positive regulation of axon regeneration
positive regulation of axonogenesis
protein heterooligomerization
positive regulation of stress fiber assembly
response to cAMP
long-term synaptic potentiation
head morphogenesis
face development
positive regulation of ERK1 and ERK2 cascade
cellular response to calcium ion
establishment of protein localization to membrane
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of synaptic vesicle exocytosis
negative regulation of endothelial cell apoptotic process
