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Invitrogen
BAFF (BLyS) (Tabalumab Biosimilar) Recombinant Rabbit Monoclonal Antibody (Tabalumab)
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BAFF (BLyS) (Tabalumab Biosimilar) Antibody (MA5-51589) in ICC/IF
Immunocytochemistry analysis of Tabalumab in paraformaldehyde fixed human peripheral blood monocytes using BAFF (BLyS) (Tabalumab Biosimilar) Recombinant Rabbit Monoclocal Antibody (Product # MA5-51589) at 10 µg/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom: primary antibody, DAPI, merg... View More
产品信息
MA5-51589
应用
建议稀释比
已发表文章
产品规格
种属反应
Cynomolgus monkey,
Human,
Rabbit
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Tabalumab
抗原
Monoclonal antibodies were generated by immunizing human immunoglobulin transgenic mice with soluble human BAFF (amino acids 133-285).
偶联物
形式
Liquid
浓度
1 mg/mL
规格
200 µg
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Tabalumab neutralises soluble and membrane-bound BAFF, inhibiting BAFF binding to BR3, TACI and BCMA. Eight mice producing serum antibody titers to human BAFF were injected intravenously with 10 µg human BAFF in phosphate buffered saline. The spleen was harvested 3 days later from each mouse and fused with myeloma cells. 20 Hybridomas were tested for specific binding to human BAFF and to make sure they were expressing human immunoglobulin heavy and light chains by enzyme-linked immunosorbent assay (ELISA). The hybridoma producing the antibody that eventually became tabalumab was a human IgG1 isotype. The antibody was then engineered to a human IgG4 isotype for complete neutralization of BAFF without depletion of BAFF-expressing cells.
MA5-51589 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
靶标信息
BAFF is a membrane bound cytokine expressed by B cell lineage cells. The soluble form of the cytokine binds to the receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is a potent B cell activator, and important for the proliferation and differentiation of B cells. BAFF is also expressed by T lymphocytes and has been shown to promote T cell activation and survival. Isoforms representing alternatively spliced, and glycosylated variants have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ApoL related ligand TALL-1; B lymphocyte stimulator; B-cell activating factor; B-cell-activating factor; B-lymphocyte stimulator; BAFF; BLyS; CD257; delta BAFF; Delta4 BAFF; Dendritic cell-derived TNF-like molecule; epididymis secretory sperm binding protein; TALL-1; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNF ligand superfamily member; TNF- and APOL-related leukocyte expressed ligand 1; TNF-like cytokine; TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor ligand 7A; Tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor superfamily member 13b; tumor necrosis factor-like protein ZTNF4
基因别名: BAFF; BLYS; CD257; DTL; TALL-1; TALL1; THANK; TNFSF13B; TNFSF20; TNLG7A; UNQ401/PRO738; ZTNF4
UniProt ID: (Human) Q9Y275
Entrez Gene ID: (Cynomolgus monkey) 102123214, (Rabbit) 100101577, (Human) 10673
B cell homeostasis
lymphocyte homeostasis
transitional one stage B cell differentiation
immune system process
germinal center formation
positive regulation of germinal center formation
immune response
cell communication
signal transduction
signaling
B cell differentiation
positive regulation of B cell proliferation
T cell costimulation
B cell costimulation
tumor necrosis factor-mediated signaling pathway
T cell proliferation
B cell proliferation
positive regulation of T cell proliferation
skin development
regulation of immune response
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