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Alomone Labs, LTD
BAI1 (extracellular) Polyclonal Antibody, FITC
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BAI1 (extracellular) Antibody (ABR-021-F-50UL) in Flow
Cell surface detection of BAI1 in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG isotype control-FITC. (green) Cells + Anti-BAI1 (extracellular)-FITC Antibody (#ABR-021-F), (2.5 µg Antibody /0.5x106cells).
产品信息
ABR-021-F-50UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)GRVRTYQFDSFLESTR, corresponding to amino acid residues 97-112 of mouse BAI1, Extracellular, N-terminus
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Adgrb1 is a phosphatidylserine receptor that enhances the engulfment of apoptotic cells, likely to be a potent inhibitor of angiogenesis in brain, and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. Adgrb1 may function in cell adhesion and signal transduction in the brain. Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. As such, tumors obtain blood supply for their growth, are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. Adgrb1 contains at least one functional p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated Adgrb1 and BAI3, which have similar tissue specificities and structures, however only Adgrb1 is transcriptionally regulated by p53. Adgrb1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. Diseases associated with ADGRB1 include Glioblastoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adhesion G protein-coupled receptor B1; Brain-specific angiogenesis inhibitor 1; FLJ41988
基因别名: ADGRB1; B830018M07Rik; BAI1; GDAIF; mKIAA4089; R75078
UniProt ID: (Human) O14514, (Mouse) Q3UHD1, (Rat) C0HL12
Entrez Gene ID: (Human) 575, (Mouse) 107831, (Rat) 362931
