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Invitrogen
BAP31 Polyclonal Antibody
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BAP31 Antibody (PA5-20199) in IHC (P)
Immunohistochemical analysis of paraffin-embedded rat lung tissue using BAP31 Polyclonal Antibody (Product # PA5-20199) at 10 µg/mL. Tissue was fixed with formaldehyde and blocked with 0.1 serum for 1 h at RT; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody overnight at 4˚C. A goat anti-rabbit IgG H&L (HRP) at 1/250 was used as secondary. Cou... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20199
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide from near the center of human BAP31.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is rat lung tissue lysate.
PA5-20199 can be used with blocking peptide PEP-0327.
靶标信息
BAP31 (B-Cell Receptor Associated Protein, 31-kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo- and hetero-oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL-2/BCL-XL-associated protein. In the C-terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 6C6 antigen; accessory protein BAP31; B-cell receptor-associated protein 31; BCR-associated protein 31; CDM protein; OTTHUMP00000025978; p28
基因别名: Bap31; Bcap31
UniProt ID: (Mouse) Q61335
Entrez Gene ID: (Rat) 293852, (Mouse) 27061
intracellular protein transport
ER to Golgi vesicle-mediated transport
immune response
positive regulation of cytosolic calcium ion concentration
spermatogenesis
biological_process
negative regulation of endoplasmic reticulum calcium ion concentration
calcium-mediated signaling using intracellular calcium source
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of mitochondrial calcium ion concentration
protein localization to endoplasmic reticulum exit site
positive regulation of intrinsic apoptotic signaling pathway
transport
apoptotic process
protein transport
vesicle-mediated transport
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
positive regulation of retrograde protein transport, ER to cytosol
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