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Abnova
BCL2L12 Polyclonal Antibody, MaxPab™
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BCL2L12 Antibody (H00083596-B01P) in WB
Western Blot analysis of BCL2L12 expression in transfected 293T cell line (H00083596-T01) by BCL2L12 MaxPab polyclonal antibody.
Lane 1: BCL2L12 transfected lysate(36.63 KDa).
Lane 2: Non-transfected lysate.
Lane 1: BCL2L12 transfected lysate(36.63 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00083596-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BCL2L12 (NP_001035758.1, 1 a.a. approximately 333 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MGRPAGLFPP LCPFLGFRPE ACWERHMQIE RAPSVPPFLR WAGYRPGPVR RRGKVELIKF VRVQWRRPQV EWRRRRWGPG PGASMAGSEE LGLREDTLRV LAAFLRRGEA AGSPVPTPPS PAQEEPTDFL SRLRRCLPCS LGRGAAPSES PRPCSLPIRP CYGLEPGPAT PDFYALVAQR LEQLVQEQLK SPPSPELQGP PSTEKEAILR RLVALLEEEA EVINQKLASD PALRSKLVRL SSDSFARLVE LFCSRDDSSR PSRACPGPPP PSPEPLARLA LAMELSRRVA GLGGTLAGLS VEHVHSFTPW IQAHGGWEGI LAVSPVDLNL PLD
靶标信息
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bcl-2 related proline-rich protein; Bcl-2-like protein 12; Bcl-2-related proline-rich protein; Bcl2-L-12; BCL2-like 12 (proline rich)
基因别名: BCL2L12; BPR
UniProt ID: (Human) Q9HB09
Entrez Gene ID: (Human) 83596
apoptotic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cellular senescence
