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Immunogen sequence: LLDRGNTRDK EASKEKGSEK GRAEGEWEDQ EALDYFSDKE SGKQKFNDSE GDDTEETEDY RQFRKSVLAD QGKSFATASH RNTEEEGLKY KSKVSLKGNR ESDGFREEKN YKLKETGYVV ERPSTTKDKH KEED
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
BCLAF1 is an intracellular, death promoting transcriptional repressor of survival genes that interacts with several members of the BCL2 family of proteins. It shows homology to the basic leucine zipper (bzip) and MYB DNA binding domains.From recent research it can be concluded that in case of apoptotic cells this protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope. When over expressed this protein induces apoptosis and can be suppressed by co-expression of BCL2 proteins. Also known as BTF, it triggers a proapoptotic signal, potentially helpful to overcome the resistance to STI571.BCLAF1 is found to express mostly in skeletal muscles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Bcl-2-associated transcription factor 1; BCL2-associated transcription factor 1; BCLAF1 and THRAP3 family member 1; BP-1; Btf; Btf-s
基因别名: BCLAF1; bK211L9.1; BTF; KIAA0164
UniProt ID: (Human) Q9NYF8
Entrez Gene ID: (Human) 9774