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Invitrogen
BCMA/CD3/Albumin (Podentamig Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA562703
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ Ig Mix
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA562703 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
靶标信息
The first protein described is a member of the TNF receptor superfamily and is mainly expressed in mature B cells. It plays an important role in B cell development and autoimmune responses. This receptor binds specifically to BAFF (also known as TNFSF13B or TALL-1), activating signaling pathways such as NF-κB and JNK (MAPK8). It also interacts with TRAF proteins, helping transmit signals that promote B cell survival and proliferation.
The CD3 complex is essential for T cell receptor (TCR) function. It consists of four subunits-gamma, delta, epsilon, and zeta-which are members of the immunoglobulin superfamily and are encoded by closely linked genes on chromosome 11. CD3 is expressed on developing thymocytes and all mature T cells, but not on B or NK cells. These subunits transmit signals from the TCR into the cell after antigen recognition. Their cytoplasmic regions contain specific tyrosine-based motifs that recruit signaling molecules and initiate pathways leading to T cell activation, proliferation, survival, or growth arrest. CD3 is found on most peripheral blood T lymphocytes (68-82%) and thymocytes (65-85%), and also on cerebellar Purkinje cells. Reduced T cell numbers can occur in some autoimmune diseases. Mutations in CD3 genes cause CD3 immunodeficiency, underscoring its critical role in immune function.
Albumin is the most abundant protein in blood serum, making up about half of total serum protein. It is a 65 kDa, globular, unglycosylated protein that circulates as a soluble monomer. Albumin acts mainly as a carrier for hormones such as steroids and thyroid hormones, as well as fatty acids, and helps maintain fluid balance in the bloodstream. It is produced in the liver as preproalbumin, which undergoes processing in the endoplasmic reticulum and Golgi apparatus to generate the mature, secreted form of albumin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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