NeoBiotechnologies

BCOR Recombinant Rabbit Monoclonal Antibody (BCOR/13087R)

Name: BCOR Recombinant Rabbit Monoclonal Antibody (BCOR\/13087R)
Brand: NeoBiotechnologies
SKU: 54880-RBM5-P1

查看其他17个BCOR抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

BCOR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BCOR Antibody (54880-RBM5-P1) in IHC (P)

Formalin-fixed, paraffin-embedded human tonsil stained with BCOR Recombinant Rabbit Monoclonal Antibody (BCOR/13087R). Inset: PBS instead of primary antibody; secondary only negative control.

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Immunogen image

Immunogen Image BCOR Recombinant Rabbit Monoclonal Antibody (BCOR/13087R)

产品信息

54880-RBM5-P1

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2-4 µg/mL

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

BCOR/13087R

抗原

Recombinant fragment (around aa 100-400) of human BCOR protein (exact sequence is proprietary).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product cellular localization: Cytoplasm.

Positive control: Colon mucosa: Staining should be strong at the surface and at least moderate at the basis of krypts.

Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.

靶标信息

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).

仅用于科研。不用于诊断过程。未经明确授权不得转售。