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Invitrogen
BDNF Monoclonal Antibody (35909), APC
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BDNF Antibody (MA5-23665) in Flow
Flow cytometry of BDNF in U‚87 MG human glioblastoma/astrocytoma cell line. Samples were incubated in BDNF monoclonal antibody (Product # MA5-23665) or isotype control. To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer and permeabilized with Flow Cytometry Permeabilization/Wash Buffer.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-23665
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
35909
抗原
Sf 21-derived recombinant human BDNF His129-Arg247
偶联物
APC
APC
APC
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
纯化类型
Protein A/G
保存液
Buffered saline solution with BSA
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, no cross-reactivity with recombinant human (rh) NT-3, rhNT-4, or rh beta -NGF is observed.
靶标信息
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: abrineurin; BDNF; growth factor; BDNF; H-BDNF; hBDNF1; hBDNF2A; hBDNF2B; hBDNF2C; hBDNF3; hBDNF4; hBDNF5; hBDNF6A; hBDNF6B; hBDNF7; neurotrophic factor; neurotrophin; proBDNF; unnamed protein product
基因别名: ANON2; BULN2
UniProt ID: (Human) P23560
Entrez Gene ID: (Human) 627
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
axon guidance
synapse assembly
circadian rhythm
negative regulation of myotube differentiation
positive regulation of neuron projection development
nerve development
brain-derived neurotrophic factor receptor signaling pathway
positive regulation of brain-derived neurotrophic factor receptor signaling pathway
nerve growth factor signaling pathway
negative regulation of neuron apoptotic process
collateral sprouting
positive regulation of collateral sprouting
neuron projection morphogenesis
modulation of synaptic transmission
positive regulation of synapse assembly
trans-synaptic signaling by BDNF, modulating synaptic transmission
regulation of protein localization to cell surface
negative regulation of apoptotic signaling pathway
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