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Immunogen sequence: MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL WWASSKKTEC PECREKWEGF PKVSILLRDA IEKLFPDAIR LRFEDIQQNN DIVQSLAAFQ KYGNDQIPLA PNTGRANQQM; Positive Samples: HepG2, SKOV3, A-549, SH-SY5Y, SW480, Mouse brain, Mouse heart, Mouse liver, Rat heart; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: bifunctional apoptosis inhibitor; Bifunctional apoptosis regulator; RING finger protein 47
基因别名: 3010001A07Rik; AI666707; AW107665; BAR; BFAR; RNF47
UniProt ID: (Human) Q9NZS9, (Rat) Q5PQN2, (Mouse) Q8R079
Entrez Gene ID: (Human) 51283, (Rat) 304709, (Mouse) 67118