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Invitrogen
BHLHE41 Monoclonal Antibody (2135CT82.1.84)
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BHLHE41 Antibody (MA5-37787) in WB
Western Blot analysis of BHLHE41 using the BHLHE41 Monoclonal Antibody (Product # MA5-37787) at a 1:4000 dilution. Lane 1: HeLa whole cell lysate, Lane 2: RD whole cell lysate, Lane 3: SH-SY5Y whole cell lysate, Lane 4: HepG2 whole cell lysate, Lane 5: Mouse brain tissue lysate, Lane 6: Mouse skeletal muscle tissue lysate, Lane 7: Rat skeletal muscle tissue lysate, Lane 8: Rat brain tissue lysate, Lane 9: CHO whole cell lysate. Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1:10,000 dilut... View More
产品信息
MA5-37787
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
2135CT82.1.84
抗原
recombinant protein of human BHLH3
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The BHLHE41 gene encodes a basic helix-loop-helix (bHLH) transcription factor located at the 12p12.1 susceptibility locus. It functions primarily as a nuclear transcriptional repressor, homodimerizing or heterodimerizing with various partners to regulate gene expression. BHLHE41 expression is highly tissue-specific and responsive to environmental cues. Genetic studies have highlighted its role in increasing xenograft tumor growth and its involvement in short sleep phenotypes. A notable mutation in BHLHE41 leads to a phenotype requiring only six hours of sleep, demonstrating its influence on sleep patterns. Moreover, BHLHE41 has been associated with osteoclast differentiation processes, indicating its involvement in cellular development. Its interaction with TFEB target genes suggests a protective role against certain types of cell death, emphasizing its complex role in cellular physiology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 2-Dec; basic helix-loop-helix domain containing, class B, 3; basic helix-loop-helix domain containing, class B3; basic helix-loop-helix family, member e41; bHLH transcriptional factor Dec2; bHLHb3; bHLHe41; Class B basic helix-loop-helix protein 3; Class E basic helix-loop-helix protein 41; Differentially expressed in chondrocytes protein 2; Enhancer-of-split and hairy-related protein 1; hDEC2; mDEC2; SHARP-1
基因别名: 6430520M22Rik; Bhlhb2l; BHLHB3; BHLHE41; DEC2; hDEC2; SHARP-1; SHARP1
UniProt ID: (Human) Q9C0J9, (Mouse) Q99PV5
Entrez Gene ID: (Human) 79365, (Rat) 117095, (Mouse) 79362
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
transcriptional repressor activity, RNA polymerase II transcription factor binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription corepressor activity
protein binding
protein homodimerization activity
histone deacetylase binding
bHLH transcription factor binding
MRF binding
protein heterodimerization activity
E-box binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
protein dimerization activity
N-box binding
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
cell proliferation
organ morphogenesis
negative regulation of myotube differentiation
negative regulation of transcription by competitive promoter binding
cell differentiation
circadian regulation of gene expression
negative regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nervous system development
circadian rhythm
entrainment of circadian clock
regulation of neuronal synaptic plasticity
regulation of transcription, DNA-templated
rhythmic process
