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Invitrogen
BIN1 Monoclonal Antibody (3B6F10)
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产品信息
MA5-31652
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
3B6F10
抗原
Purified recombinant fragment of human BIN1 (AA: 189-398) expressed in E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-31652 has been tested in indirect ELISA.
靶标信息
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AMPH 2; amphiphysin 2; Amphiphysin II; amphiphysin-like; Amphiphysin-like protein; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; Bridging integrator 1; DKFZp547F068; MGC10367; MGC105358; myc box dependent interacting protein 1; Myc box-dependent-interacting protein 1; SH3 domain-containing protein 9
基因别名: ALP-1; AMPH2; AMPHL; BIN1; BRAMP-2; SH3P9
UniProt ID: (Human) O00499, (Mouse) O08539
Entrez Gene ID: (Human) 274, (Mouse) 30948
endocytosis
multicellular organism development
regulation of endocytosis
cell differentiation
muscle cell differentiation
positive regulation of apoptotic process
positive regulation of GTPase activity
regulation of neuron differentiation
positive regulation of endocytosis
positive regulation of astrocyte differentiation
lipid tube assembly
regulation of cell cycle arrest
nucleus organization
cell proliferation
viral process
