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BIT1 Polyclonal Antibody
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FIGURE: 1 / 3
BIT1 Antibody (600-401-Z75) in ICC/IF
Immunofluorescence Microscopy of Bit1 antibody. Cell Type: human small intestine cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: Bit1 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: Bit1 is located in the mitochondrion. Staining: Bit1 as red fluorescent signal.
Product Details
600-401-Z75
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-Bit1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the internal region of human Bit1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bcl-2 inhibitor of transcription 1; cilia and flagella associated protein 37; OTTHUMP00000205936; Peptidyl-tRNA hydrolase 2, mitochondrial; PTH 2; unnamed protein product
Gene Aliases: A230072I16Rik; BIT1; CFAP37; CGI-147; IMNEPD; PTH; PTH 2; PTH2; PTRH2
UniProt ID: (Human) Q9Y3E5, (Mouse) Q8R2Y8
Entrez Gene ID: (Human) 51651, (Mouse) 217057
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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