BMP-4 Monoclonal Antibody (10F4B4)

cytokine activity protein binding growth factor activity heparin binding co-receptor binding chemoattractant activity protein serine/threonine kinase activator activity BMP receptor binding

negative regulation of transcription from RNA polymerase II promoter skeletal system development ossification angiogenesis blood vessel development osteoblast differentiation metanephros development ureteric bud development branching involved in ureteric bud morphogenesis mesoderm formation organ induction kidney development mesonephros development neural tube closure positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation vasculature development endochondral ossification blood vessel endothelial cell proliferation involved in sprouting angiogenesis chondrocyte differentiation hematopoietic progenitor cell differentiation lymphoid progenitor cell differentiation myeloid leukocyte differentiation heart morphogenesis renal system process heart induction secondary heart field specification outflow tract septum morphogenesis membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis sinoatrial node development aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion development epithelial to mesenchymal transition involved in endocardial cushion formation cardiac right ventricle morphogenesis apoptotic process involved in endocardial cushion morphogenesis cardiac septum development type B pancreatic cell development transcription from RNA polymerase II promoter germ cell development endoderm development mesoderm development mesodermal cell fate determination heart development cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation post-embryonic development anterior/posterior axis specification specification of organ position regulation of cell fate commitment gene expression regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition telencephalon development dorsal/ventral neural tube patterning telencephalon regionalization pituitary gland development negative regulation of cell-cell adhesion cell differentiation erythrocyte differentiation monocyte differentiation macrophage differentiation lung development embryonic limb morphogenesis positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway regulation of BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of BMP signaling pathway positive regulation of epithelial cell differentiation forebrain development positive regulation of protein binding negative regulation of chondrocyte differentiation positive regulation of collagen biosynthetic process negative regulation of T cell differentiation in thymus negative regulation of immature T cell proliferation in thymus embryonic hindlimb morphogenesis tendon cell differentiation deltoid tuberosity development ameloblast differentiation regulation of protein import into nucleus odontogenesis of dentin-containing tooth odontogenesis regulation of odontogenesis of dentin-containing tooth auditory receptor cell differentiation embryonic digit morphogenesis camera-type eye development positive regulation of apoptotic process positive regulation of programmed cell death cell fate commitment regulation of cell differentiation negative regulation of cell differentiation positive regulation of endothelial cell differentiation positive regulation of epidermal cell differentiation negative regulation of myoblast differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of mitotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development mesodermal cell differentiation intermediate mesodermal cell differentiation camera-type eye morphogenesis embryonic morphogenesis anatomical structure formation involved in morphogenesis regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation neuron fate commitment embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis embryonic skeletal system development smooth muscle tissue development stem cell differentiation epithelial cell proliferation positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive chemotaxis smooth muscle cell differentiation regulation of smooth muscle cell differentiation cartilage development negative regulation of multicellular organismal process cardiac muscle cell differentiation positive regulation of cardiac muscle fiber development lens induction in camera-type eye embryonic skeletal joint morphogenesis bone development cranial suture morphogenesis positive regulation of SMAD protein import into nucleus lung morphogenesis lung vasculature development epithelium development bronchus development trachea development trachea formation epithelial tube branching involved in lung morphogenesis branching involved in prostate gland morphogenesis bud elongation involved in lung branching epithelial cell proliferation involved in lung morphogenesis bud dilation involved in lung branching prostate gland morphogenesis prostatic bud formation muscle tissue development mammary gland formation epithelial-mesenchymal cell signaling negative regulation of prostatic bud formation regulation of branching involved in prostate gland morphogenesis regulation of morphogenesis of a branching structure coronary vasculature development regulation of cartilage development positive regulation of cartilage development positive regulation of branching involved in lung morphogenesis pharyngeal arch artery morphogenesis negative regulation of thymocyte apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to BMP stimulus glomerular capillary formation negative regulation of glomerular mesangial cell proliferation nephric duct formation ureter morphogenesis negative regulation of mesenchymal cell proliferation involved in ureter development regulation of branching involved in ureteric bud morphogenesis negative regulation of branching involved in ureteric bud morphogenesis negative regulation of glomerulus development positive regulation of protein localization to nucleus positive regulation of p38MAPK cascade positive regulation of odontoblast differentiation regulation of miRNA transcription negative regulation of pri-miRNA transcription from RNA polymerase II promoter pericyte cell differentiation negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration cardiac jelly development positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis regulation of mesodermal cell differentiation negative regulation of metanephric S-shaped body morphogenesis negative regulation of metanephric comma-shaped body morphogenesis positive regulation of primary miRNA processing regulation of cardiac muscle cell differentiation negative regulation of extrinsic apoptotic signaling pathway