Invitrogen

BMPR1A Monoclonal Antibody (4B7B2)

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BMPR1A Monoclonal Antibody (4B7B2)

产品信息

MA5-17036

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
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免疫组化（石蜡） (IHC (P))

1:200-1:1,000
-

流式细胞分析 (Flow)

1:200-1:400
查看1篇已发表文章 1篇已发表文章

酶联免疫吸附实验 (ELISA)

1:10,000
-
产品规格

种属反应

Human

已发表种属

Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

4B7B2

抗原

Purified recombinant fragment of human BMPR1A (amino acids: 179-378 ) expressed in E. Coli.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2538508

产品详细信息

MA5-17036 targets BMPR1A in indirect ELISA, FACS, IHC and WB applications and shows reactivity with Human samples.

The MA5-17036 immunogen is purified recombinant fragment of human BMPR1A (amino acids: 179-378 ) expressed in E. Coli.

MA5-17036 detects BMPR1A which has a predicted molecular weight of approximately 60kDa.

靶标信息

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMPR-1A; BMPRIA; bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5

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基因别名: 10q23del; ACVRLK3; ALK3; BMPR1A; CD292; SKR5

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UniProt ID: (Human) P36894

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Entrez Gene ID: (Human) 657

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功能
RNA polymerase II transcription factor activity, sequence-specific DNA binding glycoprotein binding protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding protein homodimerization activity SMAD binding metal ion binding BMP receptor activity serine/threonine protein kinase receptor
参与通路
in utero embryonic development mesoderm formation somitogenesis Mullerian duct regression positive regulation of mesenchymal cell proliferation chondrocyte differentiation outflow tract septum morphogenesis outflow tract morphogenesis cardiac conduction system development mitral valve morphogenesis tricuspid valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis endocardial cushion formation protein phosphorylation immune response transforming growth factor beta receptor signaling pathway ectoderm development dorsal/ventral axis specification regulation of cardiac muscle cell apoptotic process positive regulation of pathway-restricted SMAD protein phosphorylation neural crest cell development negative regulation of smooth muscle cell migration stem cell population maintenance pituitary gland development neural plate mediolateral regionalization signal transduction by protein phosphorylation lung development positive regulation of bone mineralization BMP signaling pathway hindlimb morphogenesis dorsal aorta morphogenesis odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter paraxial mesoderm structural organization lateral mesoderm development regulation of lateral mesodermal cell fate specification mesendoderm development embryonic organ development developmental growth positive regulation of epithelial cell proliferation negative regulation of neurogenesis palate development regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation positive regulation of SMAD protein import into nucleus heart formation pharyngeal arch artery morphogenesis cellular response to BMP stimulus positive regulation of cardiac ventricle development positive regulation of vascular smooth muscle cell proliferation regulation of cellular senescence
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