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Invitrogen
BNIP2 Polyclonal Antibody
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产品信息
PA5-49988
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from C-terminal of human BNIP2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects endogenous levels of total BNIP2 protein.
靶标信息
BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; BCL2/adenovirus E1B 19 kDa-interacting protein 2 beta; BCL2/adenovirus E1B 19kDa interacting protein 2; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2; BCL2/adenovirus E1B interacting protein 1, NIP2; BNIP 2
基因别名: 5730523P12Rik; BNIP-2; BNIP2; BNIP2beta; NIP2; Nip21; Nip2l
UniProt ID: (Human) Q12982, (Mouse) Q8K4H0
Entrez Gene ID: (Human) 663, (Mouse) 12175
apoptotic process
negative regulation of apoptotic process
positive regulation of GTPase activity
positive regulation of muscle cell differentiation
blastocyst development
positive regulation of MAPK cascade
positive regulation of neuron differentiation
positive regulation of small GTPase mediated signal transduction
striated muscle cell differentiation
centrosome organization
