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Invitrogen
BNIP3 Polyclonal Antibody
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BNIP3 Antibody (PA5-78881) in WB
Western blot analysis of BNIP3 in Lane 1: rat brain tissue lysate, Lane 2: rat kidney tissue lysate, Lane 3: rat heart tissue lysate, Lane 4: rat testis tissue lysate, Lane 5: mouse brain tissue lysate, Lane 6: mouse kidney tissue lysate, Lane 7: mouse heart tissue lysate, Lane 8: mouse testis tissue lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minute... View More
产品信息
PA5-78881
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human BNIP3 (KEFLFKHPKRTATLSMRNTSVMKK).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat brain tissue, rat kidney tissue, rat heart tissue, rat testis tissue, mouse brain tissue, mouse kidney tissue, mouse heart tissue, mouse testis tissue, human Hela whole cell, human A375 whole cell, human A549 whole cell.
靶标信息
NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3; BCL2/adenovirus E1B 19 kDa-interacting protein 3; BCL2/adenovirus E1B 19kDa interacting protein 3; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3; BCL2/adenovirus E1B interacting protein 1, NIP3
基因别名: BNIP3; NIP3
UniProt ID: (Human) Q12983, (Mouse) O55003
Entrez Gene ID: (Human) 664, (Rat) 84480, (Mouse) 12176
response to hypoxia
apoptotic process
cell death
granzyme-mediated apoptotic signaling pathway
negative regulation of mitochondrial fusion
mitochondrial protein catabolic process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of protein complex disassembly
mitochondrial fragmentation involved in apoptotic process
negative regulation of membrane potential
regulation of mitochondrial membrane permeability
autophagic cell death
brown fat cell differentiation
neuron apoptotic process
defense response to virus
response to hyperoxia
cellular response to hydrogen peroxide
cellular response to mechanical stimulus
cellular response to cobalt ion
cellular response to hypoxia
reactive oxygen species metabolic process
positive regulation of mitochondrial fission
positive regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
mitochondrial outer membrane permeabilization
toxin transport
intrinsic apoptotic signaling pathway in response to hypoxia
regulation of mitochondrion organization
negative regulation of apoptotic process
regulation of aerobic respiration
negative regulation of reactive oxygen species metabolic process
mitophagy
positive regulation of autophagy
positive regulation of cardiac muscle cell apoptotic process
positive regulation of macroautophagy
negative regulation of cell death
