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BNIP3 Antibody (710728) in ICC/IF
For immunofluorescence analysis, cobalt chloride (150 uM, 48h) treated HeLa cells were fixed with methanol for detection of BNIP3 using Anti-BNIP3 Recombinant Rabbit Superclonal™ Antibody (Product # 710728, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Cytoskeleton was stained with alpha-tubulin Monoclonal Antibody (Product # 32-2500, 1 µg/mL) followed by Goat anti-Mouse IgG Secondary Antibody, Alexa Fluor® 594 conjugate (Product # A-11032... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
710728
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
8HCLC
抗原
Protein corresponding to Human BNIP3 (aa 1-140)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Bovine and Equine.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
靶标信息
NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BCL2/adenovirus E1B 19kDa interacting protein 3; BCL2/adenovirus E1B interacting protein 3; BNIP3; Hypoxia-Activated BNIP3 Overlapping Non-coding RNA; lacks exon 2; BNIP3deltaExon2; nineteen kD interacting protein-3; pro-apoptotic mitochondrial protein; unnamed protein product
基因别名: HABON; NIP3
UniProt ID: (Human) Q12983
Entrez Gene ID: (Human) 664
mitophagy
mitophagy
response to hypoxia
positive regulation of autophagy
negative regulation of mitochondrial fusion
cardiac muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
negative regulation of mitochondrial membrane potential
positive regulation of macroautophagy
cerebral cortex development
mitochondrial protein catabolic process
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of programmed cell death
positive regulation of protein complex disassembly
mitochondrial fragmentation involved in apoptotic process
negative regulation of membrane potential
regulation of mitochondrial membrane permeability
autophagic cell death
response to axon injury
oligodendrocyte differentiation
neuron apoptotic process
positive regulation of mitochondrial calcium ion concentration
defense response to virus
response to hyperoxia
reticulophagy
substrate localization to autophagosome
cellular response to hydrogen peroxide
cellular response to mechanical stimulus
cellular response to cobalt ion
cellular response to hypoxia
reactive oxygen species metabolic process
positive regulation of mitochondrial fission
positive regulation of release of cytochrome c from mitochondria
response to oxygen-glucose deprivation
mitochondrial outer membrane permeabilization
granzyme-mediated programmed cell death signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of mitophagy
intrinsic apoptotic signaling pathway in response to hypoxia
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
