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Invitrogen
BRCA2 Polyclonal Antibody
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BRCA2 Antibody (PA5-105731) in ICC/IF
Immunofluorescent analysis of BRCA2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and BRCA2 polyclonal antibody (Product # PA5-105731) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105731
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BRCA2(Accession P51587), corresponding to amino acid residues E2070-S2120.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total BRCA2.
靶标信息
Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumor-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brca 2; brca-2; BRCA1/BRCA2-containing complex, subunit 2; Brca2; BRCA2 DNA repair associated protein; breast and ovarian cancer susceptibility gene, early onset; breast and ovarian cancer susceptibility protein 2; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer 2, mutation 1, University of Wisconsin-Madison; breast cancer susceptibility protein 2; DNA repair associated; DNA repair-associated BRCA2; FANCB; Fanconi anemia group D1 protein; fanconi anemia group D1 protein homolog; mutant BRCA2; mutant DNA repair-associated protein 2; RP11-298P3.4; transcript variant 1; unnamed protein product
基因别名: BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; RAB163; XRCC11
UniProt ID: (Human) P51587, (Mouse) P97929
Entrez Gene ID: (Human) 675, (Mouse) 12190, (Rat) 360254
protease binding
double-stranded DNA binding
single-stranded DNA binding
histone acetyltransferase activity
protein binding
protein binding, bridging
identical protein binding
gamma-tubulin binding
molecular function inhibitor activity
H3 histone acetyltransferase activity
H4 histone acetyltransferase activity
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA recombinase assembly
DNA repair
nucleotide-excision repair
double-strand break repair
DNA recombination
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
male meiosis I
negative regulation of mammary gland epithelial cell proliferation
positive regulation of transcription, DNA-templated
centrosome duplication
establishment of protein localization to telomere
cellular response to ionizing radiation
mitotic recombination-dependent replication fork processing
double-strand break repair involved in meiotic recombination
regulation of DNA damage checkpoint
oocyte maturation
inner cell mass cell proliferation
chromatin remodeling
meiosis I
spermatogenesis
brain development
cell proliferation
female gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-C
response to gamma radiation
hemopoiesis
DNA damage response, signal transduction by p53 class mediator
mammary gland development
replication fork processing
homologous chromosome orientation involved in meiotic metaphase I plate congression
regulation of cytokinesis
multicellular organism growth
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
chordate embryonic development
positive regulation of mitotic cell cycle
chromosome organization
cellular senescence
response to nutrient
response to estradiol
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