Search
Bethyl Laboratories
BRD4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
IHC-00396
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1312 and 1362 of human bromodomain-containing protein 4.
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Monkey, Gorilla and Chinese hamster
Target Information
BRD4, a ubiquitously expressed nuclear phosphoprotein, is a member of BET protein family. It is a human homolog of mouse MCAP and consists of 2 N-terminal bromodomains, a central ET-domain, and several kinase-like motifs in its N-terminus. It is expressed as 2 isoforms; the longer variant has a C-terminus region with a praline and glutamine-rich domains. BRD4 is a chromatin-binding protein whose expression is induced in response to growth stimuli. BRD4 acts at different stages of the cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth. It also has a role in regulating chromosomal dynamics during mitosis. BRD4 functions as a cellular target for E2 protein of papillomavirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: BRD4-NUT FUSION; bromodomain-containing 5; Bromodomain-containing protein 4; chromosome-associated protein; female sterile homeotic related gene 4; fsh-like protein; HUNKI; MCAP; Mitotic chromosome-associated protein; Protein HUNK1
Gene Aliases: BRD4; Brd5; CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP; WI-11513
UniProt ID: (Human) O60885, (Mouse) Q9ESU6
Entrez Gene ID: (Human) 23476, (Mouse) 57261
transcription regulatory region sequence-specific DNA binding
p53 binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
protein serine/threonine kinase activity
protein binding
RNA polymerase II carboxy-terminal domain kinase activity
enzyme binding
protein binding, bridging
histone binding
RNA polymerase II C-terminal domain binding
P-TEFb complex binding
histone H4 reader activity
histone H4K12ac reader activity
histone H4K5ac reader activity
histone H4K16ac reader activity
histone H4K8ac reader activity
histone H3K9ac reader activity
histone H3K27ac reader activity
DNA binding
regulation of transcription involved in G1/S transition of mitotic cell cycle
inner cell mass cell proliferation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
chromosome segregation
positive regulation of G2/M transition of mitotic cell cycle
chromatin modification
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation of DNA binding
histone H4-K12 acetylation
histone H3-K14 acetylation
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation by host of viral transcription
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of inflammatory response
negative regulation of DNA damage checkpoint
positive regulation of T-helper 17 cell lineage commitment
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support