Bethyl Laboratories

BRG1/SMARCA4 Polyclonal Antibody

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说明书
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BRG1/SMARCA4 Polyclonal Antibody

产品信息

IHC-00466

应用
建议稀释比
已发表文章

免疫组化 (IHC)

1:100-1:500
-

免疫组化（石蜡） (IHC (P))

1:100-1:500
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Region between residue 75 and 125 of human BRM/SWI2-Related Gene 1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, member 4).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.20 mg/mL

纯化类型

Antigen affinity chromatography

保存液

TBS, pH 7.0 to 8.0, with 0.1% BSA

内含物

0.09% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Dog, Horse, Rabbit, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Gray short-tailed opossum and hirteen-lined ground squirrel

靶标信息

Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ATP-dependent helicase SMARCA4; BAF190A; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1

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基因别名: b2b508.1Clo; b2b692Clo; BAF190; BAF190A; BRG1; CSS4; HP1-BP72; hSNF2b; MRD16; RTPS2; SMARCA4; SNF2; SNF2B; SNF2beta; SNF2L4; SNF2LB; SW1/SNF; SWI2

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UniProt ID: (Human) P51532, (Mouse) Q3TKT4

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Entrez Gene ID: (Human) 6597, (Mouse) 20586

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription coactivator activity RNA polymerase I CORE element sequence-specific DNA binding p53 binding transcription coactivator activity transcription corepressor activity helicase activity protein binding ATP binding DNA-dependent ATPase activity transcription factor binding Tat protein binding nucleosomal DNA binding protein N-terminus binding androgen receptor binding DNA polymerase binding lysine-acetylated histone binding nucleotide binding RNA polymerase II regulatory region sequence-specific DNA binding DNA binding chromatin binding hydrolase activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ATPase activity protein complex binding histone binding DNA helicase
参与通路
negative regulation of transcription from RNA polymerase II promoter neural retina development nucleosome disassembly chromatin remodeling transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter during mitosis spermatid development nervous system development covalent chromatin modification positive regulation of Wnt signaling pathway negative regulation of cell growth ATP-dependent chromatin remodeling positive regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of androgen receptor signaling pathway positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of glucose mediated signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter beta-catenin-TCF complex assembly negative regulation of G1/S transition of mitotic cell cycle cell morphogenesis blood vessel development vasculogenesis in utero embryonic development blastocyst growth blastocyst hatching liver development outflow tract morphogenesis nucleosome assembly methylation-dependent chromatin silencing regulation of transcription, DNA-templated transcription from RNA polymerase II promoter glial cell fate determination heart development positive regulation of cell proliferation DNA methylation on cytosine within a CG sequence chromatin modification stem cell population maintenance neurogenesis extracellular matrix organization keratinocyte differentiation regulation of cell migration forebrain development hindbrain development embryonic hindlimb morphogenesis aortic smooth muscle cell differentiation negative regulation of apoptotic process positive regulation of DNA binding histone H3 acetylation positive regulation of cell differentiation embryonic organ morphogenesis epidermis morphogenesis definitive erythrocyte differentiation heart trabecula formation pharyngeal arch artery morphogenesis lens fiber cell development
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