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Invitrogen
BRIP1 Recombinant Rabbit Monoclonal Antibody (HL2961)
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BRIP1 Antibody (MA5-56705) in ICC/IF
Immunocytochemistry analysis of BRIP1 using BRIP1 Recombinant Monoclonal Antibody (Product # MA5-56705) in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. BRIP1 antibody diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody (Product # MA5-31466) .
产品信息
MA5-56705
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2961
抗原
Recombinant fragment of human FANCJ.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) is a gene situated on chromosome 17q22, covering 19 exons within its 184-kb coding region to encode a protein containing 1249 amino acids. BRIP1 is integral to the DNA repair processes, specifically through its interaction with the BRCA1 gene, and is involved in the Fanconi anemia complementation group J (FANC J). Mutations in BRIP1 have been identified, playing a role in cancer predisposition with a notable eightfold increased risk for ovarian cancer and associations with cervical cancer risk through its single nucleotide polymorphisms (SNPs). Amplifications and other mutations of BRIP1 are prevalent in a variety of cancers, and its expression involves significant correlations with copy number variations (CNV) and DNA methylation across numerous tumor types. BRIP1's expression is upregulated in certain contexts, which can contribute to cancer progression, as evidenced in the Omani population with breast cancer. These interactions validate its association with DNA damage repair, cell cycle, and metabolism across multiple cancer types.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent RNA helicase BRIP1; BACH 1; BACH1 BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1/BRCA2-associated helicase 1; BRIP 1; DNA 5'-3' helicase FANCJ; FANCJ protein; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523
基因别名: BACH1; BRIP1; FANCJ; OF
UniProt ID: (Human) Q9BX63
Entrez Gene ID: (Human) 83990
DNA damage checkpoint
DNA synthesis involved in DNA repair
strand displacement
DNA replication
double-strand break repair
regulation of transcription from RNA polymerase II promoter
negative regulation of cell proliferation
DNA duplex unwinding
cellular response to vitamin
regulation of signal transduction by p53 class mediator
