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Invitrogen
BRMS1 Polyclonal Antibody
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BRMS1 Antibody (PA5-78885) in WB
Western blot analysis of BRMS1 in, Lane 1: rat kidney tissue lysates, Lane 2: rat liver tissue lysates, Lane 3: mouse liver tissue lysates, Lane 4: HELA whole cell lysates. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50 µg of sample under reducing conditions. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. The membrane was blocked with 5% Non-fat Milk/ TBS for 1. 5 hour ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-78885
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human BRMS1 recombinant protein (Position: D52-D244).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat kidney tissue, rat liver tissue, mouse liver tissue, HELA whole cell.
靶标信息
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: breast cancer metastasis suppressor 1; Breast cancer metastasis-suppressor 1; Breast cancer metastasis-suppressor 1 homolog; BRMS 1; BRMS1; unnamed protein product
基因别名: AV003220; AW554636; BRMS1
UniProt ID: (Human) Q9HCU9, (Rat) Q5M7T3, (Mouse) Q99N20
Entrez Gene ID: (Human) 25855, (Rat) 293668, (Mouse) 107392
negative regulation of transcription from RNA polymerase II promoter
apoptotic process
regulation of gene expression
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of NF-kappaB transcription factor activity
regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of protein deacetylation
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
positive regulation of anoikis
transcription, DNA-templated
histone deacetylation
regulation of transcription, DNA-templated
cellular process
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