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Invitrogen
BRSK1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20352
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
a 28 amino acid peptide from near the carboxy terminus of human BRSK1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is human brain tissue lysate.
PA5-20352 can be used with blocking peptide PEP-0472.
靶标信息
BRSK1 (SAD1) is a serine/threonine kinase, and is a UV-induced DNA damage checkpoint kinase. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BR serine/threonine-protein kinase 1; Brain-specific serine/threonine-protein kinase 1; SAD1A; serine/threonine kinase SAD-B; serine/threonine kinase SADB; Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase SAD-B
基因别名: Brsk1; Gm1100; RGD1563268; SAD-B; SADB
UniProt ID: (Rat) B2DD29, (Mouse) Q5RJI5
Entrez Gene ID: (Rat) 499073, (Mouse) 381979
magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase binding
gamma-tubulin binding
tau-protein kinase activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
protein phosphorylation
cellular response to DNA damage stimulus
neurotransmitter secretion
axonogenesis
response to UV
response to ionizing radiation
establishment of cell polarity
neuron differentiation
protein autophosphorylation
neuron projection morphogenesis
centrosome duplication
G2/M transition of mitotic cell cycle
cell cycle
nervous system development
phosphorylation
peptidyl-serine phosphorylation
G2 DNA damage checkpoint
intracellular signal transduction
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