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Invitrogen
Barecetamab Recombinant Human Monoclonal Antibody
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产品信息
MA5-59413
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Barecetamab, also known as ISU-104, is a fully human anti-ErbB3 monoclonal antibody. The ERBB3 gene, located at 12q13 on chromosome 12, encodes a transmembrane tyrosine kinase receptor that is part of the ERBB receptor family. The receptor produced by ERBB3 has a molecular weight of approximately 180 kDa and features a ligand-binding extracellular domain (ECD) with four subdomains, a transmembrane region, and an intracellular domain. Unlike other ERBB family receptors, ERBB3 lacks intrinsic kinase activity, but it can still activate downstream signaling pathways by forming heterodimers with other ErbB receptors such as EGFR and HER2. This activation is pivotal in various cellular processes, including cell proliferation and differentiation. The gene is of particular interest in oncology, as aberrant expression and mutations have been implicated in cancer pathogenesis and treatment resistance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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