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Invitrogen
Batoclimab Recombinant Human Monoclonal Antibody
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Batoclimab Antibody (MA5-42265) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human FCGRT protein expressed in CHO cells using a Batoclimab biosimilar monoclonal antibody (Product # MA5-42265). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-42265
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, lambda
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human FCGRT
偶联物
形式
Liquid
浓度
1.29 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Batoclimab (HBM9161) is a fully human antibody targeting the neonatal Fc receptor (FcRn). It targets patients with neuromyelitis optica spectrum diseases and other autoimmune diseases, and can accelerate the degradation of autoantibodies in their bodies. Batoclimab (HBM9161) is an antibody that targets the neonatal Fc receptor (FcRn). FcRn expression is up-regulated by pro-inflammatory cytokines (such as TNF-alpha) and prolongs the half-life of IgG and serum albumin by reducing lysosomal degradation in endothelial cells and bone marrow-derived cells. Blocking the FcRn-IgG interaction can accelerate the degradation of autoantibodies and reduce the onset of various pathogenic IgG-mediated autoimmune diseases, including myasthenia gravis, thyroid ophthalmopathy, neuromyelitis optica spectrum disease and immunity Thrombocytopenia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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