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Bcl-6 (Follicular Lymphoma Marker) Monoclonal Antibody (BCL6/1526)

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Bcl-6 (Follicular Lymphoma Marker) Monoclonal Antibody (BCL6/1526)

产品信息

604-MSM6-P1ABX

应用
建议稀释比
已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent
-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1-2 µg/mL
-

肽阵列 (Array)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

BCL6/1526

抗原

Recombinant human bcl-6 protein fragment (aa256-389).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: B cell CLL/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; transcriptional repressor; B-cell CLL/lymphoma 6 spliced short isoform; transcriptional repressor; zinc finger protein 51; unnamed protein product; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S

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基因别名: BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51

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UniProt ID: (Human) P41182

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Entrez Gene ID: (Human) 604

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功能
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding chromatin DNA binding identical protein binding sequence-specific DNA binding metal ion binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding
参与通路
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis regulation of cytokine production negative regulation of cell-matrix adhesion plasma cell differentiation immune system process germinal center formation regulation of germinal center formation regulation of immune system process negative regulation of type 2 immune response negative regulation of B cell apoptotic process regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response cellular response to DNA damage stimulus cell-matrix adhesion Rho protein signal transduction spermatogenesis protein localization cell proliferation pyramidal neuron differentiation actin cytoskeleton organization B cell differentiation negative regulation of cell growth positive regulation of B cell proliferation heterochromatin assembly negative regulation of mast cell cytokine production mononuclear cell proliferation negative regulation of mononuclear cell proliferation negative regulation of Rho protein signal transduction type 2 immune response B cell proliferation regulation of cell proliferation regulation of T cell proliferation regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process regulation of memory T cell differentiation T-helper 2 cell differentiation regulation of T cell differentiation positive regulation of regulatory T cell differentiation regulation of cell differentiation positive regulation of cell differentiation negative regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated isotype switching to IgE isotypes negative regulation of isotype switching to IgE isotypes erythrocyte development cell motility regulation of inflammatory response regulation of immune response positive regulation of lymphocyte activation negative regulation of plasma cell differentiation regulation of leukocyte cell-cell adhesion negative regulation of mitotic cell cycle DNA replication positive regulation of cell motility negative regulation of cellular senescence
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