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Bethyl Laboratories
Bcl11a Recombinant Rabbit Monoclonal Antibody (BLR073G)
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Bcl11a Antibody (A700-073) in WB
Detection of human Bcl11a by western blot. Samples: Whole cell lysate (50 µg) from Ramos, HEK293T, Jurkat, MOLT-4, and Raji cells prepared using NETN lysis buffer. Antibody: Rabbit anti-Bcl11a recombinant monoclonal antibody [BLR073G] (Product # A700-073 lot 2) used at 1:1,000. Secondary: HRP-conjugated goat anti-rabbit IgG (A120-101P). Detection: Chemiluminescence with an exposure time of 75 seconds. Lower Panel: Rabbit anti-COPB2 antibody (A304-523A).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
A700-073
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BLR073G
抗原
Peptide representing a region between residue 1 and 50 of human B cell CLL/lymphoma 11A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1000 µg/mL
规格
100 µg
纯化类型
purified
保存液
BBS, pH 7.8 to 8.6
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell lymphoma/leukemia 11A; BCL-11A; BCL11 transcription factor A; COUP-TF interacting protein 1; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein; Ecotropic viral integration site 9 protein homolog; EVI-9; FLJ10173; FLJ34997; myeloid leukemia; Zinc finger protein 856
基因别名: 2810047E18Rik; BCL-11A; BCL11A; CTIP1; D930021L15Rik; EVI9; Evi9a; Evi9b; Evi9c; KIAA1809; mKIAA1809; ZNF856
UniProt ID: (Mouse) Q9QYE3
Entrez Gene ID: (Mouse) 14025
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
nucleic acid binding
transcription corepressor activity
protein binding
metal ion binding
protein heterodimerization activity
DNA-binding transcription factor
zinc finger transcription factor
C2H2 zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of gene expression
positive regulation of neuron projection development
negative regulation of neuron projection development
protein sumoylation
B cell differentiation
T cell differentiation
negative regulation of collateral sprouting
positive regulation of collateral sprouting
regulation of dendrite development
negative regulation of nucleic acid-templated transcription
negative regulation of dendrite development
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