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Invitrogen
Beclin 1 Monoclonal Antibody (117CT2.5.1.1)
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Beclin 1 Antibody (MA5-37470) in IHC (P)
Immunohistochemistry analysis of Beclin 1 in formalin-fixed and paraffin-embedded human brain. Samples were incubated with Beclin 1 monoclonal antibody (Product # MA5-37470) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-37470
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgM, kappa
分类
Monoclonal
类型
Antibody
克隆号
117CT2.5.1.1
抗原
purified His-tagged recombinant full length human Autophagy BECN1
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1-beta; beclin1-gamma; coiled-coil myosin-like BCL2-interacting protein; partial ORF; putative; testis secretory sperm-binding protein Li 215e; unnamed protein product
基因别名: ATG6; beclin1; VPS30
UniProt ID: (Human) Q14457
Entrez Gene ID: (Human) 8678
autophagosome assembly
mitophagy
response to hypoxia
cytoplasmic pattern recognition receptor signaling pathway
protein targeting to lysosome
autophagy
cellular defense response
cellular response to nitrogen starvation
mitotic metaphase plate congression
JNK cascade
circadian rhythm
response to xenobiotic stimulus
response to iron(II) ion
response to lead ion
regulation of autophagy
positive regulation of autophagy
macroautophagy
regulation of macroautophagy
response to nutrient levels
regulation of cytokinesis
receptor catabolic process
response to vitamin E
cellular response to amino acid starvation
phosphatidylinositol-3-phosphate biosynthetic process
p38MAPK cascade
cellular response to glucose starvation
negative regulation of apoptotic process
negative regulation of programmed cell death
engulfment of apoptotic cell
early endosome to late endosome transport
late endosome to vacuole transport
positive regulation of protein kinase B signaling
SMAD protein signal transduction
positive regulation of stress granule assembly
protein-containing complex assembly
cellular response to hydrogen peroxide
cellular response to aluminum ion
cellular response to copper ion
cellular response to epidermal growth factor stimulus
cellular response to oxygen-glucose deprivation
autophagosome maturation
response to mitochondrial depolarisation
positive regulation of attachment of mitotic spindle microtubules to kinetochore
negative regulation of lysosome organization
positive regulation of autophagosome assembly
positive regulation of intrinsic apoptotic signaling pathway
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