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Alomone Labs, LTD
Bestrophin-2 (extracellular) Polyclonal Antibody
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Bestrophin-2 (extracellular) Antibody (ABC-002-200UL) in IHC (P)
Expression of Bestrophin-2 in rat colon - Immunohistochemical staining of rat colon paraffin embedded sections using Anti-Bestrophin-2 (extracellular) Antibody (#ABC-002), (1:100), (brown). BEST2 is expressed in the columnar absorptive cells of the colonic epithelium (arrows). Hematoxilin is used as the counterstain.
产品信息
ABC-002-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)DPAQGYKDHTLD, corresponding to amino acid residues 259-270 of mouse Bestrophin-2, 3rd extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Best2 forms calcium-sensitive chloride channels and is permeable to bicarbonate. The Best2 gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in the Best2 gene is associated with vitelliform macular dystrophy. The Best2 gene is mainly expressed in the retinal pigment epithelium and colon. Diseases associated with BEST2 include Vitelliform Macular Dystrophy and Bestrophinopathy.
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生物信息学
蛋白别名: Bestrophin-2; Bestrophin-2a; Hbest2; vitelliform macular dystrophy 2-like 1; Vitelliform macular dystrophy 2-like protein 1; VMD2-like gene 1; VMD2L-1
基因别名: BEST2; VMD2L1
UniProt ID: (Human) Q8NFU1, (Mouse) Q8BGM5
Entrez Gene ID: (Human) 54831, (Rat) 364973, (Mouse) 212989
