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Agrisera
BiP/Lumenal-binding protein Polyclonal Antibody, DyLight™ 594
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产品信息
AS09-481-DL594
产品规格
种属反应
Algae,
Fungi,
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide derived from Arabidopsis thaliana BiP proteins: BiP1, BiP2, BiP3.
偶联物
激发/发射光谱
587/614 nm
查看光谱
形式
Liquid
规格
40 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store at 4°C for 12-18 months, A preservative may be added for long time storage up to 2 years. Spin briefly the tube before use.
Specific Species Reactivity: Arabidopsis thaliana, Brassica napus, Chlamydomonas reinhardtiiCucumis sativus, Nicotiana benthamiana, Raphanus sativa L, Tokinashi-daikon, Olea europaea, Picea abies, Physcomitrella patens, Spinacia oleracea, Solanum lycopersicum, Solanum tuberosum, Triticum aestivum, Zeay mays
靶标信息
BiP is an HSPA5-encoded member of the Hsp70 chaperone family that resides primarily in the endoplasmic reticulum (ER) lumen via an N-terminal signal peptide that mediates ER import and a C-terminal ER-retention motif (KDEL); under stress it can also relocalize to additional compartments, including the cell surface. Structurally, BiP is a ~78 kDa ATP-dependent chaperone organized into a conserved N-terminal nucleotide-binding (ATPase) domain and a C-terminal substrate-binding domain with a lid region, enabling cycles of ATP binding and hydrolysis to regulate client engagement and release. Functionally, BiP is a central ER proteostasis factor that binds nascent and misfolded polypeptides to promote folding and assembly, helps maintain ER integrity, and supports disposal of aberrant proteins through ER-associated degradation; it also acts as a key regulator of the unfolded protein response by binding the luminal domains of ER stress sensors (including IRE1, PERK, and ATF6) under basal conditions and being titrated away by accumulating unfolded proteins to permit signaling that restores ER homeostasis or, if stress is unresolved, contributes to downstream cell fate decisions such as autophagy and apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BIP; BiP-L; BIP1; BIP2; BIP3; luminal binding protein; MJC20.12; MJC20_12; T26D3.10; T26D3_10
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