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Invitrogen
Blimp-1 Monoclonal Antibody (E.995.1)
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图: 1 / 4
Blimp-1 Antibody (MA5-14879) in WB
Western Blot was performed using Anti-Blimp-1 Monoclonal Antibody (E.995.1) (Product # MA5-14879) and a 92 kDa band corresponding to PR domain zinc finger protein 1 was observed across cell lines and tissue tested; was downregulated in Daudi upon MG132 treatment and upregulated in MDA-MB-231 upon TGF beta1 treatment. Whole cell extracts (30 µg lysate) of Raji (Lane 1), A549 (Lane 2), Daudi (Lane 3), Daudi treated with MG132 (1 µMpl/L for 24 hrs) (Lane 4), Ramos (Lane 5), MDA-MB-231 (Lane 6), MDA-MB-231 treated with TGF beta1 (5 ng/mL for 2... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-14879
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
E.995.1
抗原
Synthetic peptide corresponding to residues surrounding Val90 of human PRDI-BF1
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
10 µg/mL
规格
1 µg
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus. It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B lymphocyte induced maturation protein; B lymphocyte-induced maturation protein 1; B-lymphocyte-induced maturation protein 1; beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP 1; MGC118922; MGC118923; MGC118924; MGC118925; OTTHUMP00000016918; OTTHUMP00000202173; PR domain 1; PR domain containing 1 with ZNF domain isoform 2; PR domain containing 1, with ZNF domain; PR domain-containing protein 1; PRDI BF1; PRDI-BF1; PRDI-BF1 alpha; PRDI-BF1 beta; PRDI-binding factor-1; RP1-134E15.1; transcriptional repressor; binds specifically to the PRDI element in the promoter of the beta-interferon gene; drives the maturation of B-lymphocytes into Ig secreting cells; unnamed protein product
基因别名: b2b1765Clo; BLIMP-1; BLIMP1; PRDI-BF1; ZNFPR1A1
UniProt ID: (Human) O75626, (Mouse) Q60636
Entrez Gene ID: (Human) 639, (Mouse) 12142
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
histone methyltransferase binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
histone deacetylase binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
morphogenesis of a branching structure
kidney development
embryonic placenta development
maternal placenta development
heart valve development
cardiac septum development
ventricular septum development
regulation of transcription from RNA polymerase II promoter
germ cell development
post-embryonic development
gene expression
positive regulation of gene expression
negative regulation of gene expression
peptidyl-arginine methylation
negative regulation of B cell proliferation
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of natural killer cell differentiation
regulation of extrathymic T cell differentiation
aorta development
regulation of cell proliferation
eye photoreceptor cell development
cell fate commitment
positive regulation of B cell differentiation
artery morphogenesis
cellular developmental process
regulation of NK T cell differentiation
retinal bipolar neuron differentiation
intestinal epithelial cell development
trophoblast giant cell differentiation
coronary vasculature development
sebum secreting cell proliferation
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