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Agrisera
BoNT-B/Botulinum toxin B Polyclonal Antibody
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产品信息
AS16-4087
产品规格
种属反应
Bacteria
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant BoNT/B-HC (heavy chain), residues 857, 1291, expressed in E.coli.
偶联物
形式
Lyophilized
规格
500 µg
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Lyophilized antibody can be stored at -20°C for up to 3 years. Re-constituted antibody can be stored at 4°C for several days to weeks. Once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 250 µL of sterile water.
Specific Species Reactivity: Clostridium botulinum
靶标信息
Clostridium botulinum Toxin B (BoNT/B) is one of the protein neurotoxins produced by the bacteria Clostridium botulinum, which is a Gram-positive, anaerobic organism. BoNT/B, along with other botulinum toxins, is a primary virulence factor responsible for causing botulism, a serious and potentially fatal condition characterized by flaccid paralysis. BoNT/B specifically targets peripheral nerve terminals, inhibiting the release of neurotransmitters by cleaving synaptic vesicle-associated proteins, thus preventing synaptic vesicle fusion with the nerve terminal membrane. This blockade at neuromuscular junctions leads to prolonged muscle paralysis. Structurally, BoNT/B, like other botulinum toxins, consists of a heavy chain and a light chain connected by a disulfide bond. The heavy chain facilitates binding to neuronal cells and translocation into the cytosol, while the light chain acts as a protease to cleave specific proteins involved in neurotransmitter release.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bont/B; bontB; botB; cntB
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