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Bethyl Laboratories
Bovine Lactoferrin Polyclonal Antibody
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产品信息
A10-126A
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 6.8 to 7.4
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
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生物信息学
蛋白别名: CKRX; Kaliocin 1; Kaliocin1; Lactoferricin H; Lactoferrin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH
基因别名: Lf; LTF
UniProt ID: (Bovine) P24627
Entrez Gene ID: (Bovine) 280846
ossification
regulation of cytokine production
innate immune response in mucosa
proteolysis
ion transport
antibacterial humoral response
antifungal humoral response
killing of cells of other organism
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of tumor necrosis factor production
negative regulation of ATPase activity
positive regulation of osteoblast proliferation
positive regulation of toll-like receptor 4 signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation by host of viral process
negative regulation of viral genome replication
positive regulation of osteoblast differentiation
defense response to Gram-negative bacterium
positive regulation of NF-kappaB transcription factor activity
membrane disruption in other organism
iron ion homeostasis
bone morphogenesis
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of protein serine/threonine kinase activity
positive regulation of bone mineralization involved in bone maturation
negative regulation of single-species biofilm formation in or on host organism
positive regulation of chondrocyte proliferation
negative regulation of cysteine-type endopeptidase activity
negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
negative regulation of osteoclast development
