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Rockland
Bst2 Polyclonal Antibody
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FIGURE: 1 / 1
Bst2 Antibody (600-401-Z95) in WB
Western Blot of Bst2 antibody. Lane A: Daudi cell lysate at 1 µg/mL. Lane B: Daudi cell lysate at 2 µg/mL. Load: 35 µg per lane. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 19.1 kDa, ~22 kDa for Bst2.
Product Details
600-401-Z95
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-Bst2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid synthetic peptide near the N-terminus of the mouse Bst2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bone marrow stromal antigen 2; BST-2; CD317; DAMP-1 protein homolog; HM1.24 antigen; NPC-A-7; PDCA-1; Tetherin
Gene Aliases: 2310015I10Rik; Bst-2; BST2; C87040; CD317; DAMP-1; GREG; TETHERIN
UniProt ID: (Human) Q10589, (Mouse) Q8R2Q8
Entrez Gene ID: (Human) 684, (Mouse) 69550
immune system process
response to virus
regulation of actin cytoskeleton organization
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
negative regulation of viral genome replication
innate immune response
defense response to virus
negative regulation of intracellular transport of viral material
negative regulation of plasmacytoid dendritic cell cytokine production
humoral immune response
cell-cell signaling
multicellular organism development
cell proliferation
negative regulation of endopeptidase activity
negative regulation of cell growth
negative regulation of cell migration
B cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
type I interferon signaling pathway
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