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Invitrogen
C/EBP alpha Polyclonal Antibody
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C/EBP alpha Antibody (PA5-77911) in WB
Western blot analysis of C/EBP alpha in various whole cell extracts (30 µg). Samples were incubated with C/EBP alpha polyclonal antibody (Product # PA5-77911) using a dilution of 1:500 followed by HRP-conjugated anti-rabbit IgG. Separated by 10% SDS-PAGE. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-77911
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Sheep
已发表种属
Bovine,
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human C/EBP alpha. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.59 mg/mL
规格
59 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: THP-1, HL-60, C2C12, HepG2, NB4, U937, THP-1, MV4-11
Predicted Reactivity: Rat (100%), Sheep (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C EBP; C/EBP alpha; CCAAT/enhancer-binding protein alpha; OTTHUMP00000220269
基因别名: C/ebpalpha; CBF-A; CEBP; CEBPA
UniProt ID: (Mouse) P53566
Entrez Gene ID: (Sheep) 101118553, (Mouse) 12606
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase I regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
transcription factor binding
kinase binding
protein domain specific binding
protein complex binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
HMG box domain binding
basic leucine zipper transcription factor
urea cycle
negative regulation of transcription from RNA polymerase II promoter
liver development
embryonic placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase I promoter
transcription from RNA polymerase II promoter
mitochondrion organization
Notch signaling pathway
multicellular organism development
cholesterol metabolic process
negative regulation of cell proliferation
cytokine-mediated signaling pathway
myeloid cell differentiation
macrophage differentiation
lung development
granulocyte differentiation
regulation of cell proliferation
glucose homeostasis
fat cell differentiation
positive regulation of fat cell differentiation
positive regulation of osteoblast differentiation
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
cell maturation
inner ear development
white fat cell differentiation
brown fat cell differentiation
lipid homeostasis
cellular response to lithium ion
cellular response to organic cyclic compound
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