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Invitrogen
C/EBP epsilon Polyclonal Antibody
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C/EBP epsilon Antibody (PA5-121171) in WB
Western blot analysis of C/EBP epsilon in extracts of various cell lines. Samples were incubated with C/EBP epsilon Polyclonal antibody (Product # PA5-121171) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-121171
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human CEBPE (NP_001796.2).
偶联物
形式
Liquid
浓度
1.88 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: NCI-H460, Mouse spleen. The target is usually found in the following locations: Nucleus.
Immunogen sequence: MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE EQLLSDLFAV KPAPEARGLK GPGTPAFPHY LPPDPRPFAY PPHTFGPDRK ALGPGIYSSP GSYDPRAVAV KEEPRGPEGS RAASRGSYNP LQYQVAHCGQ TAMHLPPTLA APGQPLRVLK APLATAAPPC SPLLKAPSPA
靶标信息
C/EBP alpha regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP alpha uses a bipartite structural motif to bind DNA. Two protein chains dimerize through a set of amphipathic alpha helices termed the leucine zipper. Highly basic polypeptide regions emerge from the zipper to form a linked set of DNA contact surfaces. C/EBP alpha appears to function exclusively in terminally-differentiated, growth-arrested cells. Additional family members include C/EBP beta, C/EBP gamma, C/EBP delta and C/EBP epsilon, all of which exhibit similar DNA-binding specificities and affinities to C/EBP alpha. Furthermore, C/EBP beta and C/EBP delta readily form heterodimers both with each other as well as with C/EBP alpha.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C EBP; C/EBP epsilon; C/EBP-related protein 1; C/EBPepsilon; CCAAT/enhancer binding protein (C/EBP), epsilon; CCAAT/enhancer binding protein epsilon; CCAAT/enhancer-binding protein epsilon
基因别名: C/EBP-epsilon; C/EBPe; CEBPE; CRP1; Gm294
UniProt ID: (Human) Q15744, (Mouse) Q6PZD9
Entrez Gene ID: (Human) 1053, (Mouse) 110794
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein homodimerization activity
protein heterodimerization activity
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
basic leucine zipper transcription factor
transcription from RNA polymerase II promoter
phagocytosis
defense response
macrophage differentiation
cytokine biosynthetic process
defense response to bacterium
positive regulation of transcription from RNA polymerase II promoter
cellular response to lipopolysaccharide
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of gene expression
