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Invitrogen
C. botulinum BoNT-D Heavy Chain Monoclonal Antibody (682810)
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产品信息
MA5-61696
产品规格
种属反应
Bacteria
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
682810
抗原
E. coli-derived recombinant Clostridium botulinum Neurotoxin Type D Heavy Chain, Asn862-Glu1276
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
The BoNT-D Heavy Chain is a crucial component of botulinum neurotoxin type D (BoNT-D), which is produced by Clostridium botulinum, a gram-positive, spore-forming bacterium known for causing botulism. BoNT-D is one of the seven serotypes of botulinum toxin, each of which is highly potent and capable of causing severe paralytic illness. The heavy chain of BoNT-D plays a vital role in the neurotoxin's mechanism of action. It is responsible for binding to specific receptors on the surface of nerve cells and facilitating the internalization of the toxin into the cell. Once inside, the heavy chain aids in the translocation of the light chain into the cytoplasm, where the light chain exerts its enzymatic activity by cleaving SNARE proteins, thereby inhibiting neurotransmitter release and leading to flaccid paralysis. Understanding the structure and function of the BoNT-D heavy chain is essential for the development of antitoxins and therapeutic interventions. This knowledge is also crucial for advancing medical applications of botulinum toxins in treating conditions such as muscle spasticity, chronic pain, and other disorders related to neurotransmission. Research into the heavy chain of BoNT-D not only helps in managing botulism but also expands the potential therapeutic uses of botulinum toxins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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