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Invitrogen
C. botulinum BoNT-D Light Chain Monoclonal Antibody (695004)
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产品信息
MA5-61617
产品规格
种属反应
Bacteria
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
695004
抗原
E. coli-derived recombinant C. botulinum BoNT-D Light Chain, Thr2-Ser428
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
The gene encoding the BoNT-D Light Chain is part of the botulinum neurotoxin type D (BoNT-D) produced by Clostridium botulinum, a gram-positive, spore-forming bacterium. BoNT-D is one of the seven serotypes of botulinum toxin, which are highly potent neurotoxins causing botulism, a severe paralytic illness. The BoNT-D toxin is synthesized as a single polypeptide and subsequently cleaved into a heavy chain and a light chain. The light chain (LC) of BoNT-D is a zinc-dependent endopeptidase responsible for the neurotoxin's enzymatic activity. It specifically cleaves synaptobrevin, a SNARE protein essential for the fusion of synaptic vesicles with the presynaptic membrane, thereby inhibiting the release of acetylcholine at the neuromuscular junction. This inhibition leads to flaccid paralysis, the hallmark of botulism. Understanding the structure and function of the BoNT-D light chain is crucial for the development of antitoxins and therapeutic interventions. Additionally, research into this and other botulinum neurotoxins has broad implications, ranging from public health and biodefense to potential medical applications in treating muscle disorders and other conditions involving neurotransmission.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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