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Invitrogen
C11orf54 Polyclonal Antibody
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产品信息
PA5-59062
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV KGICGKTRIA EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 93%.
靶标信息
C11orf54, also known as Chromosome 11 Open Reading Frame 54, is an ester hydrolase highly conserved across various species. Located on chromosome 11, the gene is identified as a biomarker associated with renal cancers, although its precise biological function is not fully elucidated. Research has shown that C11orf54 plays a role in DNA repair mechanisms, particularly by blocking chaperone-mediated autophagy (CMA). Silencing this gene reduces cellular proliferation and heightens DNA damage and apoptosis when cells are treated with cisplatin, a common chemotherapeutic agent. This suggests C11orf54's involvement in cancer pathology, particularly its potential impact on DNA repair pathways, thereby supporting cell survival post DNA damage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ester hydrolase C11orf54; Ester hydrolase C11orf54 homolog
基因别名: C11orf54; LP4947; PTD012; PTOD012
UniProt ID: (Human) Q9H0W9, (Rat) Q5U2Q3
Entrez Gene ID: (Human) 28970, (Rat) 363016
