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Invitrogen
C11orf54 Polyclonal Antibody
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C11orf54 Antibody (PA5-78481) in ICC/IF
C11orf54 Polyclonal Antibody detects C11orf54 protein at nucleus by immunofluorescent analysis. Sample: HCT116 cells were fixed in 4% paraformaldehyde/PBS for 15 min. Green: C11orf54 protein stained by C11orf54 Polyclonal Antibody (Product # PA5-78481) diluted at 1:2,000. Blue: Hoechst 33342 staining.
产品信息
PA5-78481
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human C11orf54. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: A549, H1299, HCT116
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
C11orf54, also known as Chromosome 11 Open Reading Frame 54, is an ester hydrolase highly conserved across various species. Located on chromosome 11, the gene is identified as a biomarker associated with renal cancers, although its precise biological function is not fully elucidated. Research has shown that C11orf54 plays a role in DNA repair mechanisms, particularly by blocking chaperone-mediated autophagy (CMA). Silencing this gene reduces cellular proliferation and heightens DNA damage and apoptosis when cells are treated with cisplatin, a common chemotherapeutic agent. This suggests C11orf54's involvement in cancer pathology, particularly its potential impact on DNA repair pathways, thereby supporting cell survival post DNA damage.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ester hydrolase C11orf54
基因别名: C11orf54; LP4947; PTD012; PTOD012
UniProt ID: (Human) Q9H0W9
Entrez Gene ID: (Human) 28970
