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Invitrogen
C19orf10 Recombinant Rabbit Monoclonal Antibody (K01_2K59)
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产品信息
MA563957
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_2K59
抗原
Recombinant protein of human SF20 (aa 53-153).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: HNVGPGDKYT CMFTYASQGG TNEQWQMSLG TSEDHQHFTC TIWRPQGKSY LYFTQFKAEV RGAEIEYAMA YSKAAFERES DVPLKTEEFE VTKTAVAHRP G
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Pig - 92%, Cynomolgus monkey - 100%.
靶标信息
The interleukins are a broad family of well characterized cytokines, primarily of hematopoietic cell origin. Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. IL-25 (also called SF20/IL-25) is a secreted bone marrow stroma-derived growth factor cytokine that is derived from Th2 T-cells. IL-25 belongs to the IL-17 cytokine family and is capable of amplifying allergic type inflammatory responses by its actions on other cell types. IL-25 binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation. Infusion of mice with IL-25 induces IL-4, IL-5, and IL-13 gene expression. IL-25 induced mice also develop epithelial cell hyperplasia, increased mucus secretion, and airway hyperreactivity, suggesting that IL-25 may be an important mediator of allergic disease via production of IL-4, IL-5, IL-13 and eotaxin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CS010; IL 25; IL 27; interleukin 25; interleukin 27 working designation; interleukin-25; Interleukin25; MYDGF; Myeloid-derived growth factor; R33729 1; R337291; stromal cell-derived growth factor SF20; UPF0556 protein C19orf10
基因别名: C19orf10; EUROIMAGE1875335; IL25; IL27; IL27w; MYDGF; R33729_1; SF20
UniProt ID: (Human) Q969H8
Entrez Gene ID: (Human) 56005
angiogenesis
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
apoptotic process
positive regulation of phosphatidylinositol 3-kinase signaling
IRE1-mediated unfolded protein response
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein kinase B signaling
