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Invitrogen
C19orf52 Polyclonal Antibody
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C19orf52 Antibody (PA5-100225) in ICC/IF
Immunofluorescent analysis of C19orf52 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and C19orf52 polyclonal antibody (Product # PA5-100225) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-100225
产品规格
种属反应
Human,
Mouse,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TIMM29(Accession Q9BSF4), corresponding to amino acid residues H205-Q255.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total C19orf52.
靶标信息
TIMM29, also known as C19orf52, is identified as a novel subunit of the human TIM22 complex, which plays a critical role in the mitochondrial inner membrane. This protein is crucial for the stability of the TIM22 complex, which is responsible for the translocation of hydrophobic inner mitochondrial membrane proteins carrying internal targeting signals. TIMM29/C19orf52 is integrated into the mitochondrial inner membrane, exposing its C-terminus to the intermembrane space, and is vital for mitochondrial function and protein import pathways. This gene's importance is underscored by its involvement in processes related to mitochondrial integrity and its potential role in neurodegenerative disorders and viral interactions, such as those with the hepatitis B virus (HBV).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mitochondrial import inner membrane translocase subunit Tim29; TIM29; uncharacterized protein C19orf52 homolog
基因别名: c19orf52; TIMM29
UniProt ID: (Mouse) Q8BGX2, (Human) Q9BSF4
Entrez Gene ID: (Mouse) 69773, (Human) 90580
