Invitrogen

C1S (Active) Monoclonal Antibody (M241)

Name: C1S (Active) Monoclonal Antibody (M241)
Brand: Invitrogen
SKU: MA5-48987

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

MA5-48987

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:50

免疫组化（石蜡） (IHC (P))

1:50

免疫组化（冰冻） (IHC (F))

1:50

流式细胞分析 (Flow)

1:50

免疫沉淀 (IP)

1:50

功能检测 (Functional)

1:50

抑制试剂 (IA)

1:50

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

M241

抗原

Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

100 µg/mL

纯化类型

Protein G

保存液

PBS with 0.1% BSA

内含物

no preservative

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

AB_3091069

产品详细信息

The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s

靶标信息

Activated C1s is a protein complex involved in the complement system, which is a part of the innate immune system. C1s is a serine protease that cleaves C4 and C2 in the classical pathway of complement activation, leading to the formation of C3 convertase. The activation of C1s is initiated by binding of C1q to antigen-antibody complexes or other ligands. The C1s protein is encoded by the C1S gene, which is located on chromosome 12. Dysregulation of the complement system and C1s activation has been implicated in various diseases, including autoimmune disorders, infections, and inflammatory conditions.

仅用于科研。不用于诊断过程。未经明确授权不得转售。